Key result
Diabetic rats show increased SolM c-Fos expression during acute hemorrhage, indicating sensitivity to circulatory collapse.
Why the study?
The study was conducted to elucidate the involvement of the Bezold-Jarisch reflex in response to acute hemorrhage in diabetic rats by assessing c-Fos expression in the nucleus of the solitary tract.
Does acute hemorrhage or phenylephrine infusion alter c-Fos expression in the SolM and hemodynamic/autonomic responses differently in diabetic versus non-diabetic rats?
Does acute hemorrhage or phenylephrine infusion alter c-Fos expression in the SolM and hemodynamic/autonomic responses differently in diabetic versus non-diabetic rats?
Diabetic rats exhibit increased sensitivity to acute blood loss, leading to circulatory collapse via accelerated parasympathetic activity (Bezold-Jarisch reflex) and increased c-Fos expression in the solitary nucleus.
Answers are grounded in this paper and cite their sources.
May warrant caution during hemorrhage in diabetes; animal data leaves open human translation.
Examination of circulatory dynamics and autonomic nerve activity in acute hemorrhage in diabetic (DM) rats revealed that despite decreased receptor sensitivity to arterial blood pressure, the DM rats experienced a decline in the heart rate and acceleration of the parasympathetic nerve activity at the sympathoinhibitory phase in response to bleeding (Bezold–Jarisch [B–J] reflex). To elucidate the involvement of the B–J reflex as a reaction to acute hemorrhage in DM rats by assessing c-Fos-positive cell (c-Fos) expression in the nucleus of the solitary tract (SolM), the primary relay nucleus of the baroreflex, Streptozotocin-induced DM and non-DM rats underwent controlled-graded bleeding or continuous phenylephrine infusion under conscious state. Changes in hemodynamics and autonomous nervous system caused by acute hemorrhage and continuous phenylephrine infusion were examined by analyzing blood pressure–heart rate variability. Furthermore, effects of hemorrhage and phenylephrine infusion on the expression of c-Fos in SolM were examined. DM rats showed increased c-Fos expression in response to acute blood loss in the SolM. Non-DM rats showed the same phenomenon in response to continuous phenylephrine infusion in the SolM. Significant interactions between DM and Non-DM rats were observed among hemodynamic and autonomic response to acute hemorrhage and continuous phenylephrine infusion. DM rats were sensitive to acute blood loss, and the circulatory system easily collapsed with accelerating parasympathetic activity in the form of the B–J reflex.
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Aiji Sato (2023) studied Diabetes mellitus and acute hemorrhage. Controlled-graded bleeding or continuous phenylephrine infusion vs. Non-DM rats was evaluated on c-Fos expression in the nucleus of the solitary tract (SolM) and hemodynamic/autonomic response. Diabetic rats showed increased c-Fos expression in the solitary nucleus medial region in response to acute blood loss, indicating sensitivity to hemorrhage and circulatory collapse.
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