Key result
Acetylstrophanthidin evoked reflex bradycardia, hypotension, and withdrawal of renal sympathetic nerve activity by augmenting the inhibitory influence of cardiac receptors with vagal afferents.
Why the study?
Does acetylstrophanthidin reduce renal sympathetic nerve activity via cardiac vagal afferents in dogs?
Does acetylstrophanthidin reduce renal sympathetic nerve activity via cardiac vagal afferents in dogs?
Acetylstrophanthidin induces reflex withdrawal of renal sympathetic nerve activity via cardiac vagal afferents, providing a potential mechanism for digitalis-induced diuresis in heart failure.
No takes yet. Share an insight, caveat, or question.
May explain digitalis diuresis via vagal afferents in HF; hypothesis-generating, requires human validation.
M D Thames (1979) studied this question. Acetylstrophanthidin was evaluated on Renal sympathetic nerve activity, heart rate, and arterial pressure. Acetylstrophanthidin evoked reflex bradycardia, hypotension, and withdrawal of renal sympathetic nerve activity by augmenting the inhibitory influence of cardiac receptors with vagal afferents.
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