Key result
Rapid changes in extracellular calcium revealed an apparent diffusion coefficient for calcium ions in ventricular transverse tubules of 0.95 x 10(-6) cm2/s, much slower than in bulk solution.
The slow diffusion of calcium ions in ventricular transverse tubules suggests a high degree of tortuosity or ion binding sites within the tubular membranes.
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Slow T-tubule Ca2+ diffusion in animal hearts warrants caution before clinical extrapolation; leaves open its role in human ventricular function.
Shepherd et al. (1998) studied this question. Rapid changes of extracellular calcium concentration was evaluated on Rate of diffusion of calcium ions (changes in peak calcium current). Rapid changes in extracellular calcium revealed an apparent diffusion coefficient for calcium ions in ventricular transverse tubules of 0.95 x 10(-6) cm2/s, much slower than in bulk solution.
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