Key result
Angiotensin II infusion acutely increased plasma ANP concentrations from 5.99 to 53.76 pmol/l, but did not affect BNP or CNP levels.
Why the study?
Does angiotensin II infusion acutely affect circulating levels of A, B, and C-type natriuretic peptides?
Does angiotensin II infusion acutely affect circulating levels of A, B, and C-type natriuretic peptides?
Angiotensin II acutely stimulates the release of ANP, but not BNP or CNP, suggesting a dissociation in the short-term regulation of natriuretic peptides.
Answers are grounded in this paper and cite their sources.
Angiotensin II selectively raises ANP acutely without affecting BNP or CNP; leaves open dissociated natriuretic peptide regulation in disease.
We have evaluated the differential release of A, B and C-type natriuretic peptides in response to incremental doses of angiotensin II (2, 4 and 6 ng kg-1 min-1). Baseline plasma concentrations of ANP (5.99 +/- 0.74 pmol 1-1) were significantly (P < 0.05) higher than BNP (1.53 +/- 0.48 pmol 1-1) or CNP (0.41 +/- 0.11 pmol 1-1). Angiotensin II infusion caused a significant (P < 0.05) increase in plasma ANP to 53.76 +/- 17.3 pmol 1-1 at 6 ng kg-1 min-1. Plasma concentrations of BNP and CNP were not significantly affected by angiotensin II. Arterial blood pressures and systemic vascular resistance increased (P < 0.001) in response to angiotensin II infusion. Thus, ANP, unlike BNP or CNP, is released acutely in response to the pressor stimulus of angiotensin II. This may represent a dissociation in release of the natriuretic peptides, in terms of short and long term responses to activation of the renin-angiotensin system.
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Cargill et al. (1994) studied this question. Angiotensin II vs. Baseline was evaluated on Plasma concentrations of A, B and C-type natriuretic peptides (p=< 0.05). Angiotensin II infusion acutely increased plasma ANP concentrations from 5.99 to 53.76 pmol/l, but did not affect BNP or CNP levels.
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