Key result
A high-sodium diet significantly increased plasma human brain natriuretic peptide levels compared to a normal-sodium diet (2.04 vs 1.33 pmol/l; P<0.05).
Why the study?
Does dietary sodium loading increase plasma human brain natriuretic peptide-like immunoreactivity in normotensive subjects?
Does dietary sodium loading increase plasma human brain natriuretic peptide-like immunoreactivity in normotensive subjects?
Dietary sodium loading significantly increases plasma BNP levels in healthy normotensive subjects, suggesting BNP plays a role in sodium homeostasis.
Answers are grounded in this paper and cite their sources.
May support BNP in sodium homeostasis among normotensives; leaves open clinical relevance and requires confirmation in larger studies.
The effect of dietary sodium loading on plasma human brain natriuretic peptide-like immunoreactivity (hBNP-li) was examined in 11 normotensive subjects aged 20-23 years. Plasma hBNP-li increased significantly with increasing dietary sodium intake, with levels of 1.33 +/- 0.17 pmol/l on day 5 of a normal-sodium diet (24-h urinary sodium excretion of 171 +/- 16 mmol) and 2.04 +/- 0.10 pmol/l (P less than 0.05, versus normal-sodium diet) on day 5 of a high-sodium diet (24-h urinary sodium excretion 503 +/- 36 mmol). Corresponding plasma atrial natriuretic factor levels were 5.6 +/- 1.7 pmol/l and 11.0 +/- 2.0 pmol/l (P less than 0.05, versus normal-sodium diet) on the normal- and high-sodium diets, respectively. These results suggest that, in addition to atrial natriuretic factor, BNP may be a new and important natriuretic peptide which regulates sodium homeostasis in man during increased sodium intake.
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Lang et al. (1991) studied Normotensive (n=11). High-sodium diet vs. Normal-sodium diet was evaluated on Plasma human brain natriuretic peptide-like immunoreactivity (hBNP-li) (p=<0.05). A high-sodium diet significantly increased plasma human brain natriuretic peptide levels compared to a normal-sodium diet (2.04 vs 1.33 pmol/l; P<0.05).
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