March 1, 1971The Journal of General PhysiologyOpen Access

Membrane Currents in Mammalian Ventricular Heart Muscle Fibers Using a Voltage-Clamp Technique

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Population

Bundles of sheep ventricular fibers

Design

Preclinical

Authors

GGGerhard GiebischYale University SWSilvio WeidmannUniversity of Leeds

Discussion

Member takes

Implication

Challenges K+-centric repolarization models in sheep; leaves open translation to human arrhythmias or therapy.

Structured PICO

Population

Bundles of sheep ventricular fibers

Intervention

Voltage-clamp technique utilizing a modified sucrose gap technique and intracellular voltage control applied at preselected times during an action potential

Outcome

Membrane currents (inward and outward) during repolarizationsurrogate

Repolarization in sheep ventricular fibers is driven by a time-dependent decrease in inward sodium and calcium currents rather than an increase in outward potassium currents.

Cite This Study

Giebisch et al. (1971) studied this question.

synapsesocial.com/papers/6a090a4e2757fd3263d3aa9f https://doi.org/10.1085/jgp.57.3.290

View Full Paper

Ask AI

Bookmark

Membrane Currents in Mammalian Ventricular Heart Muscle Fibers Using a Voltage-Clamp Technique

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Membrane Currents in Mammalian Ventricular Heart Muscle Fibers Using a Voltage-Clamp Technique

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider