Why the study?
Do adult survivors of childhood and adolescent cancer have an increased risk of cardiovascular disease compared to their siblings?
Population
14,358 five year survivors of cancer diagnosed under the age of 21 with leukaemia, brain cancer, Hodgkin's…
Comparison
Childhood cancer and its treatments vs 3,899 siblings of cancer survivors
Design
Cohort
Follow-up
up to 30 years after diagnosis
Authors
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May support intensified cardiac surveillance in childhood cancer survivors; leaves open optimal prevention strategies pending prospective trials.
Do adult survivors of childhood and adolescent cancer have an increased risk of cardiovascular disease compared to their siblings?
Adult survivors of childhood cancer face a 4- to 6-fold increased risk of major cardiac events compared to siblings, strongly associated with anthracycline and radiation exposure.
Mulrooney et al. (2009) studied this question.
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