Key result
In healthy normotensive individuals, one week of a high-salt diet did not significantly affect peak early diastolic strain rate or other parameters of diastolic function compared to a low-salt diet.
Why the study?
Does subacute excess dietary salt intake affect diastolic function in healthy young normotensive individuals?
RCT (n=13)
Single-blind
Randomized crossover
No
Does subacute excess dietary salt intake affect diastolic function in healthy young normotensive individuals?
Subacute excess dietary sodium intake does not affect diastolic function in healthy young normotensive individuals, but diastolic strain rate is highly preload-dependent.
Answers are grounded in this paper and cite their sources.
Short-term high-salt intake does not affect diastolic function in healthy normotensives; leaves open preload dependence of strain measures in other populations.
AIMS: Chronic excess salt intake may have blood pressure-independent adverse effects on the heart such as myocardial hypertrophy and fibrosis. Effects of subacute sodium loading with excess dietary salt on diastolic function in normotensive individuals have been conflicting and the mechanisms are poorly understood. METHODS AND RESULTS: Thirteen healthy normotensive subjects (age 24 ± 4 years) entered a 2-week crossover study with 1 week of a low-salt diet <10 mEq/day and 1 week of a high-salt diet >200 mEq/day. At the end of each study week, left ventricular dimensions, systolic, and diastolic function were assessed with echocardiography before and after 2 L of normal saline infusion. One week of high-salt and low-salt diets did not lead to differences in echocardiographic parameters of systolic or diastolic function, even after rapid volume expansion with saline infusion. The peak early diastolic strain rate (SR) increased after volume loading both after completion of low-salt (1.62 ± 0.23/s vs. 1.82 ± 0.14/s, P < 0.05) and high-salt diets (1.67 ± 0.16/s vs. 1.86 ± 0.22/s, P < 0.05). There was a positive correlation between the peak early diastolic SR and the cardiac index (r = 0.52, P = 0.017). CONCLUSION: In healthy normotensive individuals, subacute excess dietary sodium intake does not affect diastolic function. The peak early diastolic SR, similar to other mitral Doppler and tissue Doppler parameters of diastolic function, appears to be strongly dependent on pre-load.
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Mak et al. (2013) conducted an RCT in Healthy normotensive individuals (n=13). High-salt diet vs. Low-salt diet (10 mEq/day) was evaluated on Peak early diastolic strain rate (SR peak E) in /s. In healthy normotensive individuals, one week of a high-salt diet did not significantly affect peak early diastolic strain rate or other parameters of diastolic function compared to a low-salt diet.
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