Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress
Key result
A 7-day high-sodium diet impaired cutaneous microvascular function compared to a low-sodium diet in normotensive, salt-resistant adults (80% vs 93% CVCmax; P<0.05), independent of blood pressure.
Why the study?
Does a short-term high-sodium diet impair cutaneous microvascular function in normotensive salt-resistant adults?
Population
12 normotensive adults with salt resistance, mean age 31 ± 2 years.
Comparison
7-day high-sodium diet (350 mmol/day) vs 7-day low-sodium diet (20 mmol/day)
Design
RCT, randomized to a 7 day low-sodium and 7 day high-sodium diet in random order
Follow-up
7 days per diet phase
Authors
Discussion
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Implication
High-sodium intake impairs cutaneous microvascular function independent of BP; extends evidence of BP-independent vascular effects to normotensive adults.
Study Design
Type
RCT (n=12)
Randomization
randomized
Structured PICO
Does a short-term high-sodium diet impair cutaneous microvascular function in normotensive salt-resistant adults?
P
Population
12 normotensive, salt-resistant adults (mean age 31) underwent a randomized controlled feeding study of 7-day low-sodium and 7-day high-sodium diets.
I
Intervention
7-day high-sodium diet (350 mmol/day)
C
Comparator
7-day low-sodium diet (20 mmol/day)
O
Outcome
Cutaneous microvascular function measured as plateau percentage of maximal cutaneous vascular conductance (% CVCmax) during local heating-induced vasodilatationsurrogate
Main Result
Absolute Event Rate: 80% vs 93%
p-value: p=<0.05
Short-term dietary sodium loading impairs microvascular function independent of blood pressure changes in healthy normotensive adults, likely mediated by oxidative stress.
Cite This Study
Greaney et al. (2012) conducted an RCT in Normotensive adults with salt resistance (n=12). High-sodium diet vs. Low-sodium diet (20 mmol day-1) was evaluated on Cutaneous microvascular function (plateau % CVCmax during local heating-induced vasodilatation) (p=<0.05). A 7-day high-sodium diet impaired cutaneous microvascular function compared to a low-sodium diet in normotensive, salt-resistant adults (80% vs 93% CVCmax; P<0.05), independent of blood pressure.