What question did this study set out to answer?

To determine whether endothelium-dependent vasodilation is impaired in salt-sensitive hypertensive individuals compared to salt-resistant individuals across different levels of dietary sodium.

October 1, 1997American Journal of Hypertension

Impairment of Endothelial Function in Salt-Sensitive Hypertension in Humans

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Why the study?

Is endothelium-dependent vasodilation impaired in salt-sensitive compared to salt-resistant hypertensive patients?

Population

15 untreated hypertensive male patients, age 29 to 54 years. Divided into salt-sensitive and salt-resistant…

Comparison

Salt-sensitive hypertension phenotype vs Salt-resistant hypertension phenotype

Design

Cohort

Follow-up

2 weeks (1 week sodium restricted, 1 week high salt)

Authors

AMAya MiyoshiKagoshima Medical Center

Discussion

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Implication

Impaired endothelial function may mark salt-sensitive hypertension; hypothesis-generating for endothelial-targeted strategies but should not yet change practice.

Key Points

To determine whether endothelium-dependent vasodilation is impaired in salt-sensitive hypertensive individuals compared to salt-resistant individuals across different levels of dietary sodium.
Assessed 15 untreated hypertensive male patients (aged 29–54 years) during 1 week of a low-sodium diet (5 g/day) followed by 1 week of a high-sodium diet (20 g/day).
Stratified subjects into salt-sensitive (n=6; ≥10% increase in 24-hour mean arterial pressure on high sodium) and salt-resistant (n=9; <10% increase) cohorts.
Measured forearm blood flow responses to intra-arterial acetylcholine, sodium nitroprusside, norepinephrine, and L-NMMA using strain-gauge venous plethysmography at the end of each dietary phase.
Dose-dependent vasodilation to acetylcholine was significantly lower in salt-sensitive patients compared to salt-resistant patients (P < .05), irrespective of low- or high-sodium diet phases.
Forearm vascular responses to sodium nitroprusside, norepinephrine, and L-NMMA did not significantly differ between the salt-sensitive and salt-resistant groups under either diet.

Structured PICO

Is endothelium-dependent vasodilation impaired in salt-sensitive compared to salt-resistant hypertensive patients?

Population

15 untreated hypertensive male patients, age 29 to 54 years. Divided into salt-sensitive (n=6) and salt-resistant (n=9) groups based on blood pressure response to sodium loading.

Intervention

Salt-sensitive hypertension phenotype (defined as 24-h mean increase of arterial pressure ≥ 10% after a high salt diet of 20 g/day for 1 week following a 1-week sodium restriction of 5 g/day)

Comparator

Salt-resistant hypertension phenotype (defined as < 10% increase in arterial pressure)

Outcome

Forearm vascular responses to acetylcholine, sodium nitroprusside, norepinephrine, and L-NMMA measured by strain-gauge venous plethysmographysurrogate

Salt-sensitive hypertensive patients exhibit impaired endothelium-dependent vasodilation independent of sodium intake, suggesting baseline endothelial dysfunction contributes to blood pressure elevation during salt loading.

Cite This Study

Aya Miyoshi (1997) studied this question.

synapsesocial.com/papers/6a6fc9fdf44fa9f079dd4748 https://doi.org/10.1016/s0895-7061(97)00226-4

Topics

Hypertension management

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Implication

Impaired endothelial function may mark salt-sensitive hypertension; hypothesis-generating for endothelial-targeted strategies but should not yet change practice.

Impairment of Endothelial Function in Salt-Sensitive Hypertension in Humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Impairment of Endothelial Function in Salt-Sensitive Hypertension in Humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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