Why the study?
Does dietary salt loading and restriction alter endogenous nitric oxide synthesis and relate to salt sensitivity in human hypertension?
Population
40 inpatients, comprising 24 with essential hypertension and 16 normotensive subjects.
Comparison
Sequential dietary salt modification… vs Baseline and normotensive control subjects.
Design
Cohort
Follow-up
Up to 24 days
Authors
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Inverse NOx-BP correlations after salt manipulation support ADMA-nitric oxide pathways in salt sensitivity; hypothesis-generating and should not yet change practice.
Does dietary salt loading and restriction alter endogenous nitric oxide synthesis and relate to salt sensitivity in human hypertension?
Modulation of nitric oxide synthesis by salt intake, potentially via changes in ADMA, may be a key mechanism underlying salt sensitivity in essential hypertension.
Fujiwara et al. (2000) studied this question.
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