January 1, 2002Blood Purification

Relationship between Salt Intake, Nitric Oxide and Asymmetric Dimethylarginine and Its Relevance to Patients with End-Stage Renal Disease

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Why the study?

Does salt intake modulate ADMA and NOx levels in hypertension, and is ADMA associated with cardiovascular events in end-stage renal disease?

Population

Patients with essential hypertension (n=24) and patients with end-stage renal disease (n=51).

Comparison

Sequential dietary intervention: low-salt diet… vs Within-subject comparison across different salt…

Design

Cohort

Follow-up

7 days per diet phase

Authors

TOTomohiro OsanaiHirosaki University NFNaoto FujiwaraToho University MSMasayuki SaitohNiigata Prefectural Central Hospital

Discussion

Member takes

Implication

ADMA may link to salt sensitivity in hypertension and higher CV events in ESRD; hypothesis-generating, no practice change without trials.

Structured PICO

Does salt intake modulate ADMA and NOx levels in hypertension, and is ADMA associated with cardiovascular events in end-stage renal disease?

Population

Patients with essential hypertension (n=24) and patients with end-stage renal disease (n=51).

Intervention

Sequential dietary intervention: low-salt diet (2 g NaCl/day), high-salt diet (20-23 g), and then low-salt diet for 7 days each (in the hypertension cohort).

Comparator

Within-subject comparison across different salt intake phases.

Outcome

Plasma levels of nitrate and nitrite (NOx), asymmetric dimethylarginine (ADMA), mean blood pressure changes, and frequency of cardiovascular events.surrogate

ADMA acts as a modulator of salt sensitivity in hypertension and serves as a cardiovascular risk factor in patients with end-stage renal disease.

Cite This Study

Osanai et al. (2002) studied this question.

synapsesocial.com/papers/6a8358311e118ec91c62d7df https://doi.org/10.1159/000063555

Topics

Hypertension management Women and heart disease

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