Population
Dahl salt-sensitive hypertensive rats, Dahl salt-resistant rats, spontaneously hypertensive rats, and…
Comparison
High-salt diet (8% NaCl) vs Low-salt diet (0.3% NaCl)
Design
Preclinical
Authors
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Hypothesis-generating for ADMA in salt-sensitive hypertension; human studies needed before clinical relevance.
ADMA may play a role in the pathogenesis of hypertension in Dahl salt-sensitive rats, independent of renal dimethylargininase content.
Matsuoka et al. (1997) studied this question.
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