Risk of infective endocarditis in patients with mitral valve prolapse: Systematic review with meta-analysis
Key result
Mitral valve prolapse is linked to ~8-fold higher infective endocarditis risk versus the general population.
- OR 7.83
- 95% CI 5.11-12.02
Why the study?
Mitral valve prolapse has been associated with an increased risk of infective endocarditis, but the magnitude of this association remained poorly quantified.
Does mitral valve prolapse increase the risk of infective endocarditis compared to the general population?
Population
Patients with mitral valve prolapse across six eligible cohort and case-control studies
Comparison
Mitral valve prolapse vs the general population
Design
Systematic review and random effects meta-analysis
Authors
Discussion
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Member takes
Implication
Alerts clinicians to elevated infective endocarditis risk in mitral valve prolapse; confirms the association via meta-analysis of six studies.
Study Design
Type
Meta-Analysis
Structured PICO
Does mitral valve prolapse increase the risk of infective endocarditis compared to the general population?
P
Population
Patients with mitral valve prolapse (MVP) from 6 cohort and case-control studies
I
Intervention
Mitral valve prolapse (exposure)
C
Comparator
General population
O
Outcome
Risk of developing infective endocarditis (IE)hard clinical
Main Result
Effect estimate: OR 7.83 (95% CI 5.11-12.02)
Patients with mitral valve prolapse have an approximately 7-fold increased risk of developing infective endocarditis compared to the general population.
Cite This Study
Marques et al. (2024) conducted a meta-analysis in Mitral valve prolapse. Mitral valve prolapse vs. General population was evaluated on Infective endocarditis (OR 7.83, 95% CI 5.11-12.02). Mitral valve prolapse was associated with a significantly higher risk of developing infective endocarditis compared to the general population (OR 7.83; 95% CI 5.11-12.02).