Key result
AF in HFrEF linked to 71 circulating proteins reflecting nervous system development.
Why the study?
Biological mechanisms in heart failure patients with versus without atrial fibrillation may differ, but circulating proteomic differences between these groups remain incompletely described.
Are there differences in circulating proteomic profiles between HFrEF patients with and without atrial fibrillation?
Population
377 patients with ambulant HFrEF
Comparison
HFrEF patients with AF vs without AF
Design
Observational cross-sectional study
Authors
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Should not yet change HFrEF-AF management; leaves open validation of these proteins as biomarkers or targets.
Observational (n=377)
Are there differences in circulating proteomic profiles between HFrEF patients with and without atrial fibrillation?
p-value: p=< .05
Patients with HFrEF and AF have distinct circulating proteomic profiles compared to those without AF, highlighting different underlying biological mechanisms.
Petersen et al. (2025) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=377). Atrial fibrillation vs. No atrial fibrillation was evaluated on Associations between AF and circulating proteins (p=< .05). Atrial fibrillation in patients with HFrEF was significantly associated with 71 distinct circulating proteins (FDR < 0.05), reflecting mechanisms like nervous system development.
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