Key result
AF in HF is linked to amyloid-beta pathway activation and ~18% higher spondin-1 levels.
Why the study?
AF and HF frequently coexist, but the underlying pathophysiological pathways in patients with both conditions remain incompletely understood.
What pathophysiological pathways are associated with the presence of atrial fibrillation in patients with heart failure?
Population
1620 patients with HF (index cohort) and 1219 patients with HF (validation cohort)
Comparison
Patients with HF and AF vs patients with HF in sinus rhythm
Design
Biomarker and pathway overrepresentation analysis with independent cohort validation
Authors
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AF in HF links to amyloid-beta activation without practice implications; leaves open causality and therapeutic relevance.
Observational (n=2,839)
What pathophysiological pathways are associated with the presence of atrial fibrillation in patients with heart failure?
In patients with heart failure, the presence of atrial fibrillation is associated with the activation of amyloid-beta related pathways, suggesting a potential shared pathophysiological mechanism.
Santema et al. (2021) conducted an observational in Heart failure and atrial fibrillation (n=2,839). Atrial fibrillation vs. Sinus rhythm was evaluated on Dysregulated circulating biomarkers and pathway overrepresentation. In patients with heart failure, atrial fibrillation was associated with activation of amyloid-beta pathways and upregulation of biomarkers including spondin-1 (fold change 1.18, P=1.33x10^-12).
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