Key result
Chronic activation of sympathetic activity has adverse biological effects in heart failure, and manipulating the β-adrenergic receptor pathway offers novel therapeutic approaches.
Population
Patients with heart failure characterized by left ventricular dysfunction
Design
Review
Authors
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Should not yet change heart failure practice; leaves open clinical validation of β-adrenergic pathway modulators.
This review summarizes the pathophysiological role of β-adrenoceptor desensitization in heart failure and explores novel therapeutic strategies targeting this pathway.
Rapacciuolo et al. (1999) conducted a review in Heart failure. Chronic activation of sympathetic activity has adverse biological effects in heart failure, and manipulating the β-adrenergic receptor pathway offers novel therapeutic approaches.
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