Key result
Cardiac imaging with 67Ga citrate detected diffuse cardiac uptake in 13 of 15 rabbits with experimental myocarditis, whereas 99mTc pyrophosphate showed no uptake in 8 rabbits.
Why the study?
Does 67Ga citrate or 99mTc pyrophosphate cardiac imaging detect experimental myocarditis in a rabbit model?
Does 67Ga citrate or 99mTc pyrophosphate cardiac imaging detect experimental myocarditis in a rabbit model?
67Ga citrate imaging, but not 99mTc pyrophosphate, successfully detects experimental myocarditis in a rabbit model.
67Ga citrate merits further preclinical study for myocarditis imaging; leaves open clinical translation and utility in humans.
The ability of 67Ga citrate and 99mTc pyrophosphate cardiac imaging to detect myocarditis was assessed in an experimental rabbit model. Twenty-three rabbits were imaged approximately 72 hours after infusion of i.v. norepinephrine. Diffuse cardiac uptake was found in 13 of 15 rabbits scanned with 67Ga. Tissue distribution studies documented significant myocardial uptake of 67Ga in those with positive scans. Precordial imaging and tissue distribution studies revealed no cardiac uptake in the eight rabbits scanned with 99mTc. Histologic examination of all 23 hearts revealed qualitatively similar, typical lesions of myocarditis. This study suggests that cardiac imaging with 67Ga may be useful in the detection of myocarditis.
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Reeves et al. (1981) studied Myocarditis (n=23). 67Ga citrate cardiac imaging vs. 99mTc pyrophosphate cardiac imaging was evaluated on Diffuse cardiac uptake. Cardiac imaging with 67Ga citrate detected diffuse cardiac uptake in 13 of 15 rabbits with experimental myocarditis, whereas 99mTc pyrophosphate showed no uptake in 8 rabbits.
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