What question did this study set out to answer?

To assess the diagnostic utility of tau and amyloid PET molecular imaging in identifying chronic traumatic encephalopathy and distinguishing post-traumatic pathology from Alzheimer's disease.

September 16, 2014Translational PsychiatryOpen Access

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury

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Authors

EMEffie MitsisRush University Medical Center SRSilvana RiggioJames J. Peters VA Medical Center LKLale KostakoğluNYU Langone Health

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Implication

Case series shows distinct tau and amyloid PET patterns in brain injury, indicating improved differentiation of chronic traumatic encephalopathy from Alzheimer's disease.

Key Points

To assess the diagnostic utility of tau and amyloid PET molecular imaging in identifying chronic traumatic encephalopathy and distinguishing post-traumatic pathology from Alzheimer's disease.
Clinical and molecular PET imaging evaluations using [(18)F]-Florbetapir (amyloid-beta) and [(18)F]-T807 (tau neurofibrillary tangles) in two male patients (N=2) presenting with progressive cognitive decline.
Evaluated a 71-year-old retired NFL athlete with multiple concussions and a 56-year-old man with frontotemporal dementia and a prior severe fall resulting in a subdural hematoma.
In the retired athlete, [(18)F]-Florbetapir PET was negative, excluding typical Alzheimer's disease, while [(18)F]-T807 PET demonstrated striatal, nigral, and hippocampal tau retention indicative of a novel subcortical CTE pattern.
In the single severe head trauma case, [(18)F]-Florbetapir PET excluded generalized Alzheimer's-type pathology but identified focal amyloid retention localized specifically to the impact site.

Cite This Study

Mitsis et al. (2014) studied this question.

synapsesocial.com/papers/6a09276ec64d0aaf94b6200d https://doi.org/10.1038/tp.2014.91

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Implication

Case series shows distinct tau and amyloid PET patterns in brain injury, indicating improved differentiation of chronic traumatic encephalopathy from Alzheimer's disease.

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury

Discussion

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Implication

Key Points

Cite This Study

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury

Discussion

Member takes

Implication

Key Points

Cite This Study

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