Key result
Ovariectomy in older female mRen2.Lewis rats on a high-salt diet significantly reduced proteinuria (0.8 vs 11.5 mg/mg creatinine; P<0.002) and protected against renal injury.
Why the study?
Does ovariectomy prevent salt-dependent renal injury in older female mRen2.Lewis rats on a high-salt diet?
Population
Older female mRen2.Lewis rats aged to 60 weeks, subjected to a high-salt (8% sodium chloride) diet for 4 weeks
Comparison
Ovariectomy (performed at 15 weeks of age) vs Intact female mRen2.Lewis rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Caution against clinical extrapolation in postmenopausal women; extends preclinical evidence on ovarian hormones in salt-sensitive renal injury.
Does ovariectomy prevent salt-dependent renal injury in older female mRen2.Lewis rats on a high-salt diet?
Absolute Event Rate: 0.8% vs 11.5%
p-value: p=<0.002
Ovariectomy in older female mRen2.Lewis rats protects against salt-induced renal injury and cardiac hypertrophy independent of blood pressure.
Yamaleyeva et al. (2007) studied Renal injury in high-salt-fed older mRen2.Lewis rats. Ovariectomy vs. Intact was evaluated on Proteinuria (mg/mg creatinine) (p=<0.002). Ovariectomy in older female mRen2.Lewis rats on a high-salt diet significantly reduced proteinuria (0.8 vs 11.5 mg/mg creatinine; P<0.002) and protected against renal injury.
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