Key result
Gene transfer of eNOS to the thick ascending limb of eNOS-/- mice restored L-arginine-induced inhibition of NaCl transport, decreasing Cl absorption to 59.7 pmol/min per mm (P<0.05).
Absolute Event Rate: 59.7% vs 100.6%
p-value: p=<0.05
Gene transfer of eNOS to the thick ascending limb of eNOS knockout mice restores L-arginine-induced inhibition of NaCl transport, indicating eNOS is essential for NO-mediated regulation of THAL NaCl transport.
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Highlights eNOS role in renal NaCl handling; hypothesis-generating for hypertension therapies, pending human validation.
Ortiz et al. (2003) studied eNOS knockout mice. Gene transfer of eNOS (Ad-NKCC2eNOS) and L-arginine vs. Ad-NKCC2GFP (GFP gene transfer) was evaluated on Cl absorption in THALs (p=<0.05). Gene transfer of eNOS to the thick ascending limb of eNOS-/- mice restored L-arginine-induced inhibition of NaCl transport, decreasing Cl absorption to 59.7 pmol/min per mm (P<0.05).
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