Key result
A high-salt diet enhanced the inhibitory effect of L-arginine on chloride absorption in rat thick ascending limbs (56% vs 29% reduction) and increased eNOS expression 3.9-fold (P<0.03).
Population
Isolated thick ascending limbs (THALs) from rats
Comparison
High-salt diet for 7 to 10 days vs Normal-salt diet for 7 to 10 days
Design
Preclinical
Follow-up
7 to 10 days
Authors
Loading...
May elucidate salt-NO interactions in renal tubules; leaves open translation to human hypertension.
Absolute Event Rate: 56% vs 29%
A high-salt diet enhances the sensitivity of the thick ascending limb to nitric oxide and increases eNOS expression, which may play a role in salt-sensitive hypertension.
Ortiz et al. (2003) studied this question. High-salt diet vs. Normal-salt diet was evaluated on Decrease in chloride absorption by 1 mmol/L L-Arginine. A high-salt diet enhanced the inhibitory effect of L-arginine on chloride absorption in rat thick ascending limbs (56% vs 29% reduction) and increased eNOS expression 3.9-fold (P<0.03).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: