August 1, 1999AJP Heart and Circulatory Physiology

Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition

View Full Paper

Ask AI

Bookmark

Why the study?

Does NOS II inhibition induce salt-sensitive hypertension in Dahl salt-resistant rats?

Population

Dahl salt-resistant (DR) rats

Design

Preclinical

Follow-up

12 days

Authors

MRMurray A. RuddWalt Disney (United States)MTMaría R. TrollietBoston University SHSusan HopeBoston University

Discussion

Member takes

Implication

Inducible NOS inhibition may induce salt sensitivity in resistant rat models; leaves open any role in human hypertension.

Structured PICO

Does NOS II inhibition induce salt-sensitive hypertension in Dahl salt-resistant rats?

Population

Dahl salt-resistant (DR) rats

Intervention

Selective NOS II inhibitor 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT) at 150 or 300 nmol/h for 12 days, plus 8% NaCl diet for 7 days. Other inhibitors tested: S-ethylisourea (EIT) and N-[3-(aminomethyl)benzyl]acetamidine hydrochloride (1400W).

Outcome

Tail-cuff systolic blood pressuresurrogate

Inhibition of inducible nitric oxide synthase (NOS II) in Dahl salt-resistant rats leads to salt-induced hypertension, suggesting NOS II plays a key role in preventing salt sensitivity.

Cite This Study

Rudd et al. (1999) studied this question.

synapsesocial.com/papers/6a707e2da7fbea1e4408195e https://doi.org/10.1152/ajpheart.1999.277.2.h732

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider