Why the study?
Does nitric oxide inhibit chloride transport to a lesser extent in thick ascending limbs from Dahl salt-sensitive rats compared to salt-resistant rats?
Population
Thick ascending limbs from Dahl salt-sensitive (DS) rats (n=7) and Dahl salt-resistant (DR) rats (n=6)
Comparison
Spermine NONOate at 10 and 100 micromol/L vs Basal state and comparison between Dahl…
Design
Preclinical
Authors
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Blunted NO-mediated chloride inhibition in salt-sensitive rat tubules may contribute to hypertension; leaves open relevance to human salt sensitivity.
Does nitric oxide inhibit chloride transport to a lesser extent in thick ascending limbs from Dahl salt-sensitive rats compared to salt-resistant rats?
The reduced ability of nitric oxide to inhibit chloride transport in the thick ascending limbs of Dahl salt-sensitive rats may contribute to the mechanism of salt-sensitive hypertension.
García et al. (1999) studied this question.
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