Key result
Selective inhibition of neural nitric oxide synthase in the renal medulla increased blood pressure by 14 +/- 1 mm Hg in rats maintained on a high sodium diet.
Why the study?
Does selective inhibition of neural nitric oxide synthase in the renal medulla alter blood pressure in rats on a high salt diet?
Population
Conscious Sprague-Dawley rats maintained on a high sodium intake
Comparison
Continuous renal medullar interstitial infusion… vs Medullary interstitial infusion of saline…
Design
Preclinical
Authors
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No immediate clinical implications; extends mechanistic evidence for renal medullary nNOS in salt-sensitive hypertension models.
Does selective inhibition of neural nitric oxide synthase in the renal medulla alter blood pressure in rats on a high salt diet?
The neural isoform of nitric oxide synthase in the renal medulla plays a role in the long-term control of blood pressure in the presence of a high salt diet.
Mattson et al. (1996) studied Blood pressure regulation. Antisense oligonucleotide targeting neural nitric oxide synthase mRNA or 7-nitroindazole vs. Saline vehicle or scrambled oligonucleotide probe was evaluated on Blood pressure. Selective inhibition of neural nitric oxide synthase in the renal medulla increased blood pressure by 14 +/- 1 mm Hg in rats maintained on a high sodium diet.
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