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March 1, 1992Journal of Clinical InvestigationOpen Access

Endothelium-derived relaxing factor inhibits transport and increases cGMP content in cultured mouse cortical collecting duct cells.

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Population

Cultured mouse cortical collecting duct cell line in the presence or absence of cow pulmonary artery…

Comparison

Bradykinin (10^-9 M) or acetylcholine (10^-7 M) vs Absence of CPAE cells, or presence of…

Design

Preclinical

Authors

BSBarbara A. StoosHenry Ford HospitalOCO. A. CarreteroNovartis (Switzerland)RFRodolfo D. FarhyHenry Ford Hospital

Discussion

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Overview

EDRF may regulate collecting duct transport; hypothesis-generating for its role in renal sodium handling in vivo.

Structured PICO

P
Population
Cultured mouse cortical collecting duct cell line (M-1) in the presence or absence of cow pulmonary artery endothelial (CPAE) cells
I
Intervention
Bradykinin (10^-9 M) or acetylcholine (10^-7 M)
C
Comparator
Absence of CPAE cells, or presence of nitroarginine (N-Arg, 10^-4 M)
O
Outcome
Short-circuit current (Isc) and cGMP contentsurrogate

Endothelium-derived relaxing factor (EDRF) inhibits active transport and increases cGMP in cortical collecting duct cells, suggesting a direct role in renal solute transport regulation.

Cite This Study

Stoos et al. (1992) studied this question.

synapsesocial.com/papers/6a7162a88031ec7bb1dcefb3https://doi.org/10.1172/jci115653
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of endothelium-derived relaxing factor and nitric oxide on rat mesangial cells1990 · 124 citations
  2. 2cGMP mediates effects of atrial peptides on medullary collecting duct cells1987 · 103 citations
  3. 3Atrial peptide and cGMP effects on NaCl transport in inner medullary collecting duct1990 · 60 citations
  4. 4Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct.1988 · 119 citations
  5. 5Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.1991 · 215 citations