Population
Monolayers of a cortical collecting duct cell line, M-1
Comparison
Simultaneous addition of bradykinin 10 M and… vs BK alone (10(-8) M) and ANF alone (10(-8) M)
Design
Preclinical
Authors
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Animal data on ANF-bradykinin synergy require human validation; leaves open translation to clinical natriuresis.
ANF and bradykinin synergistically inhibit sodium absorption in the distal nephron, a process mediated by protein kinase C and associated with a decrease in cAMP.
Stoos et al. (1992) studied this question.
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