Key result
Pentosan polysulfate improves systolic function in pressure-overloaded rats, increasing fractional shortening by ~25%.
Why the study?
Does Pentosan Polysulfate improve cardiac function and decrease ADAMTS4 expression in rats subjected to pressure overload by aortic banding?
Does Pentosan Polysulfate improve cardiac function and decrease ADAMTS4 expression in rats subjected to pressure overload by aortic banding?
Absolute Event Rate: 60% vs 48%
p-value: p=<0.01
In a rat model of pressure overload, pentosan polysulfate improved cardiac function and decreased ADAMTS4 expression, suggesting a role for ADAMTS proteases in heart failure development.
Hypothesis-generating for ADAMTS4 inhibition in pressure-overload HF; should not yet change clinical practice.
We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in atherogenesis and osteoarthritis, also play a role in heart failure development.
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Vistnes et al. (2014) studied Heart failure (pressure overload by aortic banding) (n=44). Pentosan polysulfate (PPS) vs. Vehicle (0.9% NaCl) was evaluated on Fractional shortening (FS) (p=<0.01). Pentosan polysulfate treatment improved systolic function in rats subjected to pressure overload by aortic banding, demonstrated by an improved fractional shortening of 60% versus 48% in vehicle-treated rats.
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