Key result
Cardiac lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.
Lumican is upregulated in experimental and clinical heart failure and promotes pro-fibrotic signaling in cardiac fibroblasts, suggesting a role in adverse cardiac remodeling.
No takes yet. Share an insight, caveat, or question.
Lumican may mediate fibrosis in heart failure; leaves open its value as a therapeutic target pending human studies.
Engebretsen et al. (2013) studied Heart failure. Aortic banding (mice) and in vitro mechanical/proinflammatory stimuli vs. Sham-operated mice and control human hearts was evaluated on Cardiac lumican mRNA and protein levels. Cardiac lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: