Why the study?
Does biological sex modify the blood pressure and aldosterone responses to salt intake and angiotensin II?
Population
1592 subjects from the Hypertensive Pathotype cohort, along with rat zona glomerulosa cells and a rodent…
Comparison
Chronic dietary salt manipulation and acute… vs Men vs. Women
Design
Cohort
Authors
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Sex differences in salt sensitivity may inform personalized hypertension strategies; leaves open targeted mineralocorticoid receptor blockade in women.
Does biological sex modify the blood pressure and aldosterone responses to salt intake and angiotensin II?
Women exhibit greater blood pressure salt sensitivity and aldosterone responses to Angiotensin II compared to men, suggesting they may benefit more from mineralocorticoid receptor blockade.
Shukri et al. (2018) studied this question.
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