Key result
Cardiac autoantibodies may contribute to the pathogenesis of sudden cardiac death.
Why the study?
What is the relationship between anti-cardiomyocyte autoantibodies and sudden cardiac death in autoimmune disorders?
What is the relationship between anti-cardiomyocyte autoantibodies and sudden cardiac death in autoimmune disorders?
This review highlights the potential but under-researched role of anti-cardiomyocyte autoantibodies in the pathogenesis of sudden cardiac death.
Hypothesis-generating for autoantibodies in sudden cardiac death; prospective studies needed to clarify prognostic value.
BACKGROUND: Sudden Cardiac Death (SCD) is an unexpected death caused by heart dysfunction. Autoantibodies against cardiac proteins may be potentially involved in the occurrence and progression of cardiac disease and SCD. The first report on the role of autoantibodies in idiopathic dilated cardiomyopathy appeared in the 1980s. In recent years new studies on the effects of the presence of specific autoantibodies and their relationship to ventricular arrhythmias and SCD were published. The purpose of the current mini-review is to analyze the results of the research studies focused on the relationship between anti-cardiomyocyte autoantibodies and SCD with respect to autoimmune disorders. CONCLUSION: According to our analysis, more research is needed to understand the role of these autoantibodies against cardiac proteins in the SCD pathogenesis, and potentially employ this knowledge for improving prognosis of SCD.
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Chera et al. (2018) conducted a review in Sudden Cardiac Death. Autoantibodies against cardiac proteins was evaluated. Autoantibodies against cardiac proteins may be involved in the pathogenesis of sudden cardiac death, though further research is required to fully understand their role and prognostic value.
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