Why the study?
Despite proven cardioprotective benefits across the spectrum of left ventricular dysfunction, the mechanisms by which sodium-glucose cotransport 2 inhibitors exert these effects remain poorly understood.
Design
Review
Key result
SGLT2 inhibitors provide cardioprotective benefits in heart failure across the spectrum of left ventricular dysfunction through mechanisms extending beyond glycosuria and natriuresis.
Authors
Loading...
Supports SGLT2 inhibitor use across the heart failure spectrum; leaves open the dominant nonglycosuric mechanisms.
This review summarizes the cardioprotective benefits of SGLT2 inhibitors in heart failure and explores potential mechanisms of action beyond their diuretic and glycemic effects.
Savage et al. (2024) conducted a review in Heart failure. SGLT2 inhibitors was evaluated. SGLT2 inhibitors provide cardioprotective benefits in heart failure across the spectrum of left ventricular dysfunction through mechanisms extending beyond glycosuria and natriuresis.