January 1, 2001Arthritis & Rheumatism
Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: A prospective study of 100 women
Key result
In a prospective cohort of 100 anti-Ro/SSA-positive women with connective tissue disease, the prevalence of congenital complete heart block in their newborns was 2%.
Why the study?
What is the prevalence of congenital complete heart block in infants of anti-Ro/SSA-positive women with connective tissue disease?
Population
100 anti-Ro/SSA-positive women known to have connective tissue disease followed up before and during pregnancy
Design
Cohort
Follow-up
during the index pregnancy and at birth
Authors
Discussion
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Implication
Informs preconception counseling in anti-Ro/SSA-positive pregnancies; leaves open need for larger prospective validation.
Key Points
- To prospectively determine the prevalence of congenital complete heart block and secondary neonatal electrocardiographic abnormalities in infants born to anti-Ro/SSA-positive mothers with connective tissue diseases.
- Prospective cohort study conducted across 4 referral hospitals following N=100 anti-Ro/SSA-positive women preconception and throughout pregnancy.
- Maternal antibodies to extractable nuclear antigens were evaluated using counterimmunoelectrophoresis and immunoblotting, with electrocardiography performed on a subset of newborns (n=24) across 2 centers.
- Congenital complete heart block developed in utero in 2% (2/100) of pregnancies, diagnosed at 20 and 22 weeks of gestation, resulting in zero fetal deaths.
- Cases occurred exclusively in mothers with primary Sjögren's syndrome (n=1) or undifferentiated connective tissue disease (n=1), with 0% (0/53) occurring in mothers with systemic lupus erythematosus.
- Electrocardiographic screening of 24 unselected neonates identified sinus bradycardia in 4 infants (16.7%).
Study Design
Type
Cohort (n=100)
Multicenter
Yes
Structured PICO
What is the prevalence of congenital complete heart block in infants of anti-Ro/SSA-positive women with connective tissue disease?
P
Population
100 anti-Ro/SSA-positive women known to have connective tissue disease (CTD) followed up before and during pregnancy
O
Outcome
Prevalence of congenital complete heart block (CCHB) in infantshard clinical
The risk of congenital complete heart block in infants of anti-Ro/SSA-positive women with known connective tissue disease is approximately 2%, which is useful for preconception counseling.
Cite This Study
Brucato et al. (2001) conducted a cohort in Connective tissue disease with anti-Ro/SSA antibodies in pregnancy (n=100). Anti-Ro/SSA antibodies (Exposure) was evaluated on Prevalence of congenital complete heart block (CCHB) in infants. In a prospective cohort of 100 anti-Ro/SSA-positive women with connective tissue disease, the prevalence of congenital complete heart block in their newborns was 2%.