Key result
Maternal anti-SSA antibodies were not associated with significant differences in infant QTc interval (397 vs 395 msec, P=0.57), PR interval, or heart rate compared to anti-SSA-negative controls.
Why the study?
Does maternal anti-SSA antibody status affect electrocardiographic parameters such as PR interval, QTc interval, and heart rate in infants born to mothers with connective tissue diseases?
Cohort (n=143)
Does maternal anti-SSA antibody status affect electrocardiographic parameters such as PR interval, QTc interval, and heart rate in infants born to mothers with connective tissue diseases?
Absolute Event Rate: 397% vs 395%
p-value: p=0.57
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Infants born to mothers with anti-SSA antibodies do not exhibit significant prolongation of the QTc interval or sinus bradycardia compared to infants of anti-SSA-negative mothers with connective tissue diseases.
Costedoat‐Chalumeau et al. (2004) conducted a cohort in Infants born to mothers with connective tissue diseases (n=143). Maternal anti-SSA antibodies vs. Maternal anti-SSA and anti-SSB negativity was evaluated on QTc interval during the first 2 months of life (p=0.57). Maternal anti-SSA antibodies were not associated with significant differences in infant QTc interval (397 vs 395 msec, P=0.57), PR interval, or heart rate compared to anti-SSA-negative controls.
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