What question did this study set out to answer?

To evaluate maternal autoimmune responses across different ages of diagnosis and clinical manifestations in children with congenital complete heart block.

June 1, 2004Acta Paediatrica

Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block

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Population

104 mothers of 113 children born between 1950 and 2000 and diagnosed with congenital heart block before the…

Design

Cohort

Authors

MEM. EronenUniversity of Helsinki AMAaro MiettinenUniversity of Helsinki TWTK Walle

Discussion

Member takes

Implication

Maternal antibody testing should not guide CHB prognosis or recurrence counseling; hypothesis-generating for 48-kd anti-SS-B titer in cutaneous neonatal lupus.

Key Points

To evaluate maternal autoimmune responses across different ages of diagnosis and clinical manifestations in children with congenital complete heart block.
Evaluated clinical data and maternal serum samples from 104 mothers of 113 children born between 1950 and 2000 diagnosed with congenital heart block before 16 years of age (74 prenatal, 39 postnatal diagnoses).
Measured maternal antibodies to 52 kd SS-A, 60 kd SS-A, and 48 kd SS-B using time-resolved fluoroimmunoassay and antinuclear antibodies using immunofluorescence.
Among mothers of children diagnosed in utero, 88% possessed antibodies to 52 kd SS-A, 83% had antinuclear antibodies, 48% had 60 kd SS-A, 54% had 48 kd SS-B, and 11% were seronegative across all assays.
Maternal 48 kd anti-SS-B titers were significantly higher in cases where children developed cutaneous neonatal lupus compared to those without (98.1 vs 41.0; p = 0.02).
Elevated titers in at least one assay occurred in 100% (8/8) of mothers whose children died before age 4 and 85% (11/13) whose children developed cardiomyopathy, yet antibody levels and specificities offered no overall prognostic value for clinical outcomes.

Structured PICO

Population

104 mothers of 113 children born between 1950 and 2000 and diagnosed with congenital heart block (CHB) before the age of 16 years.

Outcome

Relationship of maternal antibody levels and specificities (52 kd and 60 kd SS-A, 48 kd SS-B, ANA) to clinical outcome of children with CHB

Maternal antibody levels and specificities do not appear to have a prognostic effect on the clinical outcome of children with congenital heart block or the risk of recurrence in the same family.

Cite This Study

Eronen et al. (2004) studied this question.

synapsesocial.com/papers/6a8c81bda7928f20564e07f2 https://doi.org/10.1111/j.1651-2227.2004.tb03022.x

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Implication

Maternal antibody testing should not guide CHB prognosis or recurrence counseling; hypothesis-generating for 48-kd anti-SS-B titer in cutaneous neonatal lupus.

Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Relationship of maternal autoimmune response to clinical manifestations in children with congenital complete heart block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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