Why the study?
Do specific maternal autoantibody profiles (anti-p200, anti-Ro52, anti-Ro60) predict the development of fetal congenital heart block in high-risk pregnant patients?
Population
81 consecutive pregnant patients positive to anti-Ro±anti-La antibodies, at high risk of developing fetal…
Design
Cohort
Authors
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May support refined risk stratification in anti-Ro/La-positive pregnancies; leaves open prospective validation before guiding fetal surveillance.
Do specific maternal autoantibody profiles (anti-p200, anti-Ro52, anti-Ro60) predict the development of fetal congenital heart block in high-risk pregnant patients?
High levels of anti-p200, anti-Ro52, and anti-Ro60 antibodies identify anti-Ro/La positive pregnant women at increased risk of having a fetus with congenital heart block.
Tonello et al. (2016) studied this question.
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