January 1, 1988Lara D. Veeken

PREVALENCE OF MATERNAL Ro (SS-A) AND La (SS-B) AUTOANTIBODIES IN RELATION TO CONGENITAL HEART BLOCK

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Why the study?

Is the presence of maternal Ro (SS-A) and La (SS-B) autoantibodies associated with congenital heart block in infants?

Population

35 mothers of babies with congenital heart block, 5 mothers of babies with other types of heart block, 29…

Design

Case-control

Authors

PTPamela V. TaylorParks Victoria KTKatharine TaylorRoyal Victoria Infirmary SGSharon GriffithsUniversity of Leeds

Discussion

Member takes

Implication

Supports maternal anti-Ro/La testing in congenital heart block cases; extends observational links to fetal conduction disease but leaves causal confirmation open.

Structured PICO

Is the presence of maternal Ro (SS-A) and La (SS-B) autoantibodies associated with congenital heart block in infants?

Population

35 mothers of babies with congenital heart block, 5 mothers of babies with other types of heart block, 29 women with connective tissue disease but no babies with heart block, 445 normal pregnant women, 109 healthy nonpregnant women, and 15 babies with congenital heart block.

Comparator

Mothers of babies with other types of heart block, women with connective tissue disease but no babies with heart block, normal pregnant women, and healthy nonpregnant women.

Outcome

Prevalence of autoantibodies to ribonucleoprotein antigens (Ro/SS-A and La/SS-B)surrogate

Placental transfer of maternal anti-Ro (SS-A) or anti-La (SS-B) autoantibodies is strongly associated with and likely essential for the development of congenital complete heart block.

Cite This Study

Taylor et al. (1988) studied this question.

synapsesocial.com/papers/6a7d679c01128eec96964eb9 https://doi.org/10.1093/rheumatology/27.2.128

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Implication

Supports maternal anti-Ro/La testing in congenital heart block cases; extends observational links to fetal conduction disease but leaves causal confirmation open.

PREVALENCE OF MATERNAL Ro (SS-A) AND La (SS-B) AUTOANTIBODIES IN RELATION TO CONGENITAL HEART BLOCK

Discussion

Member takes

Implication

Structured PICO

Cite This Study

PREVALENCE OF MATERNAL Ro (SS-A) AND La (SS-B) AUTOANTIBODIES IN RELATION TO CONGENITAL HEART BLOCK

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider