Key result
Mothers of children with congenital heart block had a significantly higher antibody response to amino acids 200-239 of the Ro 52-kd protein compared to control mothers (P=0.0002).
Why the study?
Does a specific antibody profile to Ro 52-kd identify pregnant Ro/La-positive women at risk of delivering a baby with congenital heart block?
Population
9 Ro/La-positive mothers who gave birth to affected children, 8 newborns with congenital heart block, and 26…
Comparison
Analysis of antibodies against Ro 52-kd, Ro… vs Ro/La-positive mothers whose children were healthy
Design
Case-control
Authors
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Ro52 200-239 reactivity was associated with congenital heart block; hypothesis-generating for prospective risk stratification in Ro/La-positive pregnancies.
Case-Control (n=43)
Does a specific antibody profile to Ro 52-kd identify pregnant Ro/La-positive women at risk of delivering a baby with congenital heart block?
p-value: p=0.0002
A specific antibody profile to Ro 52-kd (reactivity to amino acids 200-239) may serve as a useful serologic marker to identify pregnant Ro/La-positive women at high risk of delivering a baby with congenital heart block.
Salomonsson et al. (2002) conducted a case-control in Congenital heart block (CHB) (n=43). Antibody profile to Ro 52-kd (amino acids 200-239) vs. Ro/La-positive mothers with healthy children was evaluated on Antibody reactivity to specific amino acid regions of the Ro 52-kd protein (p=0.0002). Mothers of children with congenital heart block had a significantly higher antibody response to amino acids 200-239 of the Ro 52-kd protein compared to control mothers (P=0.0002).
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