Why the study?
What is the long-term clinical outcome and autoantibody profile of mothers of children with isolated congenital heart block?
Population
33 mothers of children with isolated congenital heart block, compared with 89 healthy mothers, 45 mothers…
Design
Cohort
Follow-up
mean 11.2 years (SD 9.2 years, range 0-32 years)
Authors
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Mothers of CHB children may warrant rheumatologic surveillance; leaves open whether higher SS-A/Ro titers predict SLE progression.
What is the long-term clinical outcome and autoantibody profile of mothers of children with isolated congenital heart block?
Mothers of children with congenital heart block predominantly have subclinical primary Sjögren's syndrome and high titers of SS-A/Ro antibodies, with a significant proportion developing SLE over time.
Julkunen et al. (1993) studied this question.
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