Key result
Anti-SSA/SSB positive mothers of children with CHB face a ~63% autoimmune disease rate long-term.
Why the study?
Data on short- and long-term health outcomes of mothers of offspring with autoimmune congenital heart block are scarce.
Population
215 anti-SSA/SSB antibody-positive mothers of fetuses with high-degree CHB
Comparison
Mothers with autoimmune disease diagnosis at CHB diagnosis vs those without diagnosis
Design
Retrospective cohort study
Follow-up
Median 11 years (range 21 days to 54 years)
Authors
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May support long-term monitoring of antibody-positive mothers; leaves open optimal screening and preventive strategies.
Cohort (n=215)
Yes
Nearly half of mothers of children with congenital heart block who do not have an initial autoimmune diagnosis progress to develop one during long-term follow-up, though severe manifestations are rare.
Miniaoui et al. (2022) conducted a cohort in Autoimmune Congenital Heart Block (Maternal outcomes) (n=215). Anti-SSA/SSB antibody positivity and fetal congenital heart block was evaluated on Autoimmune disease diagnosis by the end of follow-up. Among anti-SSA/SSB antibody-positive mothers of children with congenital heart block, 63% had an autoimmune disease diagnosis by the end of a median 11-year follow-up.