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March 1, 1997Circulation Research

Arrhythmogenicity of IgG and Anti-52-kD SSA/Ro Affinity-Purified Antibodies From Mothers of Children With Congenital Heart Block

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Why the study?

Do anti-52-kD SSA/Ro antibodies induce atrioventricular block in fetal hearts?

Population

Human fetal hearts perfused by the Langendorff technique and female BALB/c mice

Design

Preclinical

Authors

MBMohamed BoutjdirElectrophysiologyLCLong ChenGuangzhou University of Chinese MedicineZZZhihao ZhangSun Yat-sen University

Discussion

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Implication

Supports mechanistic role of anti-52-kD SSA/Ro antibodies in fetal AV block; leaves open translation to human screening or prevention.

Structured PICO

Do anti-52-kD SSA/Ro antibodies induce atrioventricular block in fetal hearts?

P
Population
Human fetal hearts perfused by the Langendorff technique and female BALB/c mice
I
Intervention
IgG-enriched fractions and anti-52-kD SSA/Ro antibodies affinity-purified from sera of mothers whose children have CHB (human hearts); immunization with recombinant 52-kD SSA/Ro protein (mice)
O
Outcome
Induction of complete atrioventricular (AV) block and inhibition of L-type Ca2+ currentssurrogate

Anti-52-kD SSA/Ro antibodies are causally related to the development of congenital heart block by inducing AV block and inhibiting L-type Ca2+ currents.

Cite This Study

Boutjdir et al. (1997) studied this question.

synapsesocial.com/papers/6a703fe131a3df8243288336https://doi.org/10.1161/01.res.80.3.354
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autoantibody-Associated Congenital Heart Block: Outcome in Mothers and Children1994 · 298 citations
  2. 2L-type calcium current in rod- and spindle-shaped myocytes isolated from rabbit atrioventricular node1994 · 41 citations
  3. 3Developmental changes in membrane Ca2+ and K+ currents in fetal, neonatal, and adult rabbit ventricular myocytes.1992 · 124 citations
  4. 4Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart.1992 · 111 citations