Why the study?
Does passive transfer of human autoantibodies from mothers of children with congenital heart block induce conduction abnormalities in a murine model?
Population
Timed pregnant BALB/c mice (n=54)
Comparison
Single intravenous bolus of purified IgG… vs Controls
Design
Preclinical
Follow-up
At delivery
Authors
Loading...
Supports antibody pathogenicity in this murine model; leaves open translation to human congenital heart block.
Does passive transfer of human autoantibodies from mothers of children with congenital heart block induce conduction abnormalities in a murine model?
Passive transfer of human autoantibodies from mothers of children with congenital heart block into pregnant mice induces bradycardia and first-degree AV block in pups, supporting the pathogenic role of these antibodies.
Mazel et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: