Antibodies to Ro(SS-A) were found in 34 of 41 mothers of infants with congenital complete heart block, suggesting it may serve as a marker to identify women at risk.
Does the presence of maternal Ro(SS-A) antibodies serve as a marker for risk of congenital complete heart block in infants?
Maternal antibodies to Ro(SS-A) may serve as a marker to identify women at risk of having an infant with congenital complete heart block.
A RECENT report by Scott et al. described antibodies to a soluble tissue ribonucleoprotein antigen called Ro(SS-A) in the serum of 34 of 41 mothers who had given birth to infants with congenital complete heart block.1 Less than half the mothers had clinical evidence of connective tissue disease. The same antibody was found in 7 of 8 serum samples collected from affected infants under three months of age but in none of 13 samples obtained from older infants. The authors suggested that maternal antibody to Ro(SS-A) might serve as a marker to identify women at risk of having an infant . . .
Litsey et al. (Thu,) conducted a letter in Congenital complete heart block (n=41). Antibodies to Ro(SS-A) was evaluated on Presence of antibodies to Ro(SS-A). Antibodies to Ro(SS-A) were found in 34 of 41 mothers of infants with congenital complete heart block, suggesting it may serve as a marker to identify women at risk.