Population
10 cases of congenital heart block, their mothers, and their siblings
Design
Case_series
Follow-up
5 to 32 years after birth of affected child (for mothers)
Authors
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Mothers of infants with congenital heart block merit extended CTD surveillance; case data leave open seronegativity effects on recurrence.
Maternal autoantibodies (anti-Ro/La) are associated with congenital heart block, and mothers may remain seropositive or develop connective tissue disorders years after the birth of an affected child.
Behan et al. (1989) studied this question.
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