Why the study?
Does anti-Ro (SS-A) binding differ between a patient with congenital complete heart block and a normal HLA-identical twin?
Population
A patient (propositus) with congenital complete heart block and his normal HLA-identical twin sister
Comparison
Quantitative solid-phase assays for Ro… vs Normal HLA-identical twin sister
Design
Case_report
Authors
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Supports hypothesis of anti-Ro involvement in congenital heart block; hypothesis-generating from single case report.
Does anti-Ro (SS-A) binding differ between a patient with congenital complete heart block and a normal HLA-identical twin?
The finding of 13-fold lower anti-Ro (SS-A) binding in a patient with congenital complete heart block compared to his normal twin supports the hypothesis that anti-Ro (SS-A) may be directly involved in its pathogenesis.
Harley et al. (1985) studied this question.
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