Why the study?
Do anti-Ro/SS-A antibodies selectively bind to neonatal cardiac cells and alter membrane repolarization?
Population
Neonatal and adult rabbit cardiac tissue exposed to sera and IgG-enriched fractions from anti-Ro/SS-A…
Comparison
Sera and IgG-enriched fractions from… vs Sera containing other antibody specificities and…
Design
Preclinical
Authors
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May inform congenital heart block pathogenesis; hypothesis-generating in animal models and should not change practice.
Do anti-Ro/SS-A antibodies selectively bind to neonatal cardiac cells and alter membrane repolarization?
Anti-Ro/SS-A antibodies selectively bind to neonatal rabbit cardiac tissue and inhibit repolarization, suggesting a pathophysiologic role in congenital heart block in neonatal lupus.
Alexander et al. (1992) studied this question.
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