The localization of Ro (SS-A) antigen in the cardiac conduction system provides a potential mechanistic link to the development of congenital heart block in infants of mothers with anti-Ro antibodies.
Provides potential mechanistic link to congenital heart block; hypothesis-generating in animal models, requires human validation.
The presence of anti-Ro (SS-A) antibody in maternal serum has been associated with congenital heart block. Using human sera monospecific for anti-Ro (SS-A) antibodies in an indirect immunofluorescence assay, Ro (SS-A) antigen was found to be present in the nuclei of myocardial cells and cells of the cardiac conduction system. The possible relationship between the location of Ro (SS-A) antigen, anti-Ro (SS-A) antibody, and heart block is discussed.
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Deng et al. (1987) studied this question.
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