Why the study?
Does anti-Ro/SSA autoantibody positivity prolong the QTc interval in adult patients with connective tissue diseases?
Population
57 adult patients with connective tissue diseases
Comparison
Anti-Ro/SSA autoantibody positivity vs Anti-Ro/SSA autoantibody negativity (controls)
Design
Cross-sectional
Authors
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May warrant QTc monitoring in anti-Ro/SSA-positive CTD; leaves open arrhythmic risk and intervention need.
Does anti-Ro/SSA autoantibody positivity prolong the QTc interval in adult patients with connective tissue diseases?
Adult patients with anti-Ro/SSA-positive connective tissue diseases have a high prevalence of QTc prolongation, suggesting an increased risk for life-threatening arrhythmias.
Lazzerini et al. (2004) studied this question.
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