Key result
Augmented ANKRD1 expression represents an adaptive response of the myocardium to stress during development and various heart insults, rather than acting as a negative regulator of gene expression.
ANKRD1/CARP functions as an adaptive response factor to myocardial stress rather than a crucial negative regulator of cardiac gene expression in vivo.
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Positions ANKRD1 upregulation as adaptive to cardiac stress; challenges negative regulator model but leaves open therapeutic relevance.
Mikhailov et al. (2008) conducted a review in Heart development and disease. ANKRD1/CARP was evaluated. Augmented ANKRD1 expression represents an adaptive response of the myocardium to stress during development and various heart insults, rather than acting as a negative regulator of gene expression.
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