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February 20, 2017Journal of Visualized Experiments

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery

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Population

Mice older than 10 days of age

Design

Preclinical

Authors

AGAlejandro GranilloMethodist HospitalCPCelia A PenaTPThuy PhamHo Chi Minh City Medicine and Pharmacy University

Discussion

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Implication

Supports preclinical longitudinal assessment in murine models; leaves open clinical translation.

Structured PICO

P
Population
Mice older than 10 days of age
I
Intervention
2D echocardiography under 1% isoflurane anesthesia
O
Outcome
Measurement of Left Atrial Volume (LAV), Aorta diameter, and Pulmonary Artery (PA) diametersurrogate

This methodology provides a standardized, non-invasive 2D echocardiographic approach to measure left atrial volume and great vessel diameters in mice, enabling longitudinal assessment of diastolic dysfunction and pulmonary hypertension models.

Limitations

  • Operator dependent
  • Requires familiarization with cardiac anatomy and echocardiographic windows
  • Poor image acquisition if the mouse has a great amount of fat or rib interference
  • Prolonged use of isoflurane can cause slowing of the heart rate and hemodynamic compromise

Cite This Study

Granillo et al. (2017) studied this question.

synapsesocial.com/papers/6a092f28e0bed6b981b62c49https://doi.org/10.3791/55214

Topics

Echocardiography
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